Now this one is as different as David Lynch's The Angriest Dog In The World. The concept is simple: the artist draws (or borrows) one single piece of clip art, and uses the exact same piece of clip art for all three panels of the comic. He then makes up dialogue based on the clip art, and ends with a punchline that'll have you squirting milk out of your nose.
And this strip has been going for four years! It's updated twice weekly, on Sundays and Thursdays. It took my wife weeks to get through all the archives for this one, because she kept cracking up with laughter at least every other comic. It's not one of those "character development" comics with long-running plotlines…it's a gag a day comic. And the amazing thing is, it's sick and twisted and funny.