Girly

http://go-girly.com/

The new (well, not so much anymore) strip by Josh Lesnick, known mostly for Wendy, it's a spin-off of CuteWendy (using the same characters as Wendy, but a completely different strip), and there's lots of absurd one-off type jokes as well as the standard story strips. I think he's got a rough outline of what's going to happen in the story, but you get the impression that he's making up each strip on the fly, which would explain the occasional one-off type strip out of nowhere, and how sometimes those one-off type things can spin out into mini-arcs. It's pretty good, but I love the Marshmellow Kitty.